Welcome to the Neuroglial Epigenetic Auditory Function LabThe Neuroglial Epigenetic Auditory Function (NEAF) Lab is a collaborative neuroscience research group dedicated to unraveling experience-dependent neuroplasticity in the auditory system, from molecules to behavior, from early development through adulthood, using preclinical rat models and human studies. We are directed by Dr. Aysegul Gungor Aydin and are located at the Biomedical Research Institute of New Jersey.
We welcome enthusiastic graduate and undergraduate researchers from Rutgers, Seton Hall, and Drew Universities to join us in exploring the fascinating world of auditory neuroscience, from glial cells and epigenomes to newborn infants and beyond. |
Decoding the Auditory System:
From Genes to Behavior in Health and Disease
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The melody of a bird's song, the rhythmic flow of words in another language, the sound of our own name- each learned auditory stimulus carries profound meaning, shaping how we interpret and respond to the world around us. Our auditory system seamlessly discriminates and identifies sounds for comprehension – allowing us to understand the meanings of specific sounds. How does the auditory brain distinguish the significant sound from the insignificant? How do we encode learned sounds, and how are auditory circuits re-tuned through experience or derailed by it?
Our laboratory investigates the molecular, cellular, and circuit-level mechanisms underlying auditory neuroplasticity, in health, and in the context of neurodevelopmental disorders such as autism spectrum disorder (ASD). We approach this question at multiple levels, integrating epigenetics, neuroglial biology, systems neuroscience, and clinical neurophysiology. A central goal is to translate mechanistic discoveries into tools for early detection, biomarker development, and intervention in children at risk for language and communication disorders. Despite remarkable advances in understanding neuronal diversity, the most abundant cell type in the brain, the astrocyte, remains largely unexplored in the auditory cortex. A central goal of our lab is to push auditory neuroscience beyond its neuron-centric focus, investigating how neuroglial networks regulate synaptic plasticity and shape adaptive sound-cued behavior. Our work spans preclinical rat models and human infant studies, and is conducted in close partnership with the Torres Lab (Rutgers University), Muñoz-Ballester Lab (UMBC), and clinical teams at Morristown Medical Center, including the NICU, Newborn Nursery, and Child Development and Autism Center, and MidAtlantic Neonatology Associates (MANA). |
News from NEAF Lab |
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April 2025
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October 2025
September 2025
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July 2025
June 2025
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February 2025
January 2025
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