Welcome to Neuroglial Epigenetic Auditory Function Lab The Neuroglial Epigenetic Auditory Function (NEAF) Lab is a collaborative neuroscience research group dedicated to unraveling experience-dependent neuroplasticity in the auditory system, both in health and disease. Our lab is directed by Dr. Aysegul Gungor Aydin and is located at the Biomedical Research Institute of New Jersey.
We welcome enthusiastic graduate and undergraduate researchers from Rutgers University, Seton Hall, and Drew University to join us in exploring the fascinating world of auditory neuroscience. |
Decoding the Auditory System:
From Genes to Behavior in Health and Disease
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The melody of a bird’s song, the rhythmic flow of words in another language, or the sound of our own names -each learned auditory stimulus carries profound meaning, shaping how we interpret and respond to the world around us. Our auditory system seamlessly discriminates and identifies sounds for comprehension – allowing us to understand the meanings of specific sounds. But how does the auditory system distinguish significant sounds from the insignificant? How do we encode learned auditory information? And how are cortical and subcortical auditory regions re-tuned through experience?
Our laboratory aims to understand and identify the molecular and neural mechanisms underlying experience-dependent neuroplasticity in the auditory system, with the goal of promoting behavioral functions affected by neurodevelopmental disorders. Towards this, we integrate multi-level processes across epigenetics, circuits, and systems. Despite our knowledge of the diversity of neurons and their roles in auditory function in the mammalian brain being highly advanced, we remain largely ignorant of the most abundant cell types - astrocytes- and their function in the auditory cortex. How do astrocytes regulate auditory neural circuits and behavior? Our goal is to expand the field of auditory neuroscience beyond its neuron-centric focus by investigating the role of neuroglial networks in synaptic plasticity, with the aim of targeting them to promote circuit plasticity for adaptive sound-cued behavior. |
News from NEAF Lab |
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January 2025
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